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A young man (Jake Gyllenhaal) born without natural immunities and raised in a bubble provided by his well-intentioned but misguided mother (Swoosie Kurtz) sets out on a cross-country trek to Niagara Falls to find his wayward girlfriend (Marley Shelton) and win her back. Along the way he has many adventures. Also with Geoffrey Arend and John Carroll Lynch. The release of the film has been protested by the Immune Deficiency Foundation. [1:24 . . .

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